Melt the Butter: In a medium saucepan over medium heat, melt ½ cup unsalted butter.
Cook the Shallots and Garlic: Add 2 minced shallots and cook until translucent, about 3 minutes. Then add 2 minced garlic cloves and cook for 1-2 more minutes.
Combine Ingredients: Stir in ½ cup panko breadcrumbs, 1 teaspoon lemon zest, 2 tablespoons lemon juice, ½ teaspoon dried oregano, ½ teaspoon crushed red pepper flakes, 1 tablespoon minced parsley, and ¼ cup grated Pecorino Romano cheese. Mix until well combined, then set aside.
Heat the Wine: In a large saucepan with a lid, bring ½ cup dry white wine (or substitute) to a boil over high heat.
Cook the Clams: Add the clams to the saucepan, cover with the lid, and steam for about 3 minutes. Open the lid, and with tongs or a slotted spoon, remove any clams that have opened, placing them in a bowl. Repeat every 30 seconds until all clams are open. Set aside 3 tablespoons of the clam cooking liquid.
Cool and Arrange Clams: Allow the clams to cool slightly, then twist off one side of each shell, keeping the meat in the other side. Arrange the clams on a rimmed baking sheet.
Add Reserved Liquid: Add the 3 tablespoons of reserved cooking liquid to the breadcrumb mixture and mix well. The mixture should be slightly moist and hold together when pressed; if it seems too dry, add more clam liquid or a teaspoon of melted butter.
Pack Filling: Spoon the breadcrumb mixture onto each clam, covering the meat completely. Pour the remaining cooking liquid into the bottom of the baking sheet.
Bake the Clams: Preheat the oven to 450°F (232°C). Bake for 8-10 minutes, until the clams are bubbling and starting to crisp.
Broil for Crispiness: Turn on the broiler and broil for 1-2 minutes, watching carefully to avoid burning. Keep the baking sheet on the middle rack rather than too close to the broiler to prevent burning.
Garnish and Serve: Arrange the clams on a serving plate, sprinkle with extra parsley and a pinch of fresh lemon zest, if desired, for a burst of flavor. Serve with lemon wedges on the side and crusty bread for dipping in any remaining sauce.